Indole-3-carbinol (I3C) from Pure Encapsulations, naturally found in vegetables including broccoli, brussels sprouts, bok choy, cauliflower, kale and cabbage. Indole-3-carbinol induces phase I and phase II liver detoxification enzymes and maintains healthy estrogen metabolism. Clinical trials suggest that indole-3-carbinol supports healthy estrogen metabolism by promoting a healthy ratio of weak estrogens (2-hydroxyestrone metabolites or 2-OHE) to strong estrogens (16 alpha-hydroxyestrone metabolites or 16 alpha-OHE) in FAVOR or the WEAK, LESS POTENT estrogens. Furthermore, a placebo- controlled trial indicated that indole-3-carbinol supports cervical cell health as a result of healthy estrogen balance. Take 400-1000 mg/day depending on body weight being careful to ramp slowly. May or may not cause temporary hot flashes. Lactating or pregnant women should NOT take indole-3-carbinol.
This Indole-3-carbinol does NOT contain rosemary. Rosemary is a potent phytoestrogen that may make fibroids, endometriosis, and adenomyosis worse. The FDA banned marketing of rosemary supplements in the 1930 used to create miscarriage.
The lack of rosemary as an anti-oxidant means that the Pure Encapsulations Indole-3-Carbinol must be refrigerated. If the Pure Encapsulations Indole-3-Carbinol is NOT refrigerated it degrades 5% every 6 months at room temperature.